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…Determine TB-LAM, a commercially available, lateral-flow urine ‘strip test’ assay. A previous study, however, has shown that the LAM test had a specificity of >95% but sub-optimal sensitivity of ~50%. Solution The project team initially proposed to address this sub-optimal sensitivity by developing an ultra-sensitive aptamer detection lateral flow assay. However, technical difficulties in generating…

…colourimetric analysis of the output from the fabric-based TSH detection solution. However, it was not possible to convert this into a triaging tool, due to the poor sensitivity of the fabric-based immunoassay platform. This was because, when a LFIA device is woven on a fabric, the warp region is coated with the antibodies and the…

…people to treatment. Future tests will focus on infectious diseases and non-communicable diseases (NCDs). The aim of the current project was to develop a two-way, cloud-based network connectivity system that could provide remote quality control to testing, disease training and clinical support, and capture important data for program and health systems managers. Outcome ChipCare successfully…

…diagnose Ng ciprofloxacin susceptibility and resistance 3)      Design POCT device primer sets specific for both Ng diagnosis and ciprofloxacin susceptibility 4)      Standardize PCR conditions and evaluate the sensitivity and specificity of the test 5)      Evaluate the prototype test for sensitivity and specificity by comparison with ‘gold standard’ culture, identification and in vitro antimicrobial susceptibility testing.…

…through analysis of exhaled air in only 20 minutes. An initial study of the device with 148 subjects attending a chest disease clinic in Bangladesh demonstrated a sensitivity of 95.5% and specificity of 98.5%. A validation study demonstrated a sensitivity and specificity of 93.5% and 85.3% respectively. This research study was designed to evaluate the…

…needs of rural consumers. Through their Hands-Off approach, WaterSHED acts as a facilitator, providing technical training to small businesses, increasing demand of toilets through community sales and marketing activities, and designing innovative, affordable products consumers aspire to own. As a result, the organization has enabled the sale of more than 135,000 toilets and helped small businesses…

…cerevisiae, thereby constructing new strains of yeast to act as a cell factory for the production of aminoglycosides. The ability of these strains to produce 2-DOS and kanamycin in batch cultures containing either minimal or complex media with 3% glucose was evaluated by TLC (Thin Layer Chromatography). Outcome The results of the TLC assay demonstrated…

…available for year-round consumption in peri-urban and rural parts of Southern and Central Ghana. The project trained Ghanian farmers to successfully rear insects (palm weevil larvae) in captivity for both consumption and commercial activity. To do this, they deconstructed insect farming into all of its keys steps, and packaged the information into a simple, user-friendly…

…reducing road accidents in Nepal through an education awareness campaign, and training of first responders. The main focus was a behaviour change management program conducted through various activities, including workshops, radio and television broadcasts on road safety and street drama, and the distribution of road safety education material to the public (such as brochures, stickers…

…was developed. This diagnostic was capable of detecting all Plasmodium species with a limit of detection for Plasmodium falciparum of 2 parasites/μL of blood, which exceeds the sensitivity of microscopy (the current standard for diagnosis in the field) by ten to fifty-fold. In a blind panel of 188 patient samples from a hyper-endemic region of…