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…as an alternative to colorimetric assays on thread and this was coupled with development of a smartphone diagnostic application, to produce a semi-quantitative readout and reduce the subjectivity of the readout. The electrochemical signal was amplified using an enzymatic reaction to improve the sensitivity of the assay. In addition, the setup was on a rotating…

…entrepreneurship model of health promotion as a means of engaging youth and communities to improve sanitation and hygiene in a rural and remote Tanzanian setting. The key activities in the intervention were: Innovations in science education, including the use of the Foldscope, an origami-based microscope, as an example of frugal innovationworkshops for teachers on soap…

…Drugs that are locally available and target additional aspects of the HIV life cycle not addressed by current therapies are urgently needed. Viroporin blockers like amantadine are historically proven antivirals, but virtually no viroporin blockers exist for viruses that disproportionately affect LMICs. Solution The team sought to screen natural products to find these viroporin blockers that could…

…tested at different depths and flow rates. Once the most efficient aeration device configuration was found (i.e., number of injectors, and optimal depth and flow rate), the sensitivity of the aeration system to temperature and salt content were investigated by conducting aeration tests at 10°C, 20°C and 30°C, with water conductivities of 250 µs/cm and…

…major global health problems that frequently co-occur in endemic areas, and can be diagnosed simultaneously in fecal samples by microscopy-based methods. However, microscopy-based methods are limited by low sensitivity, are tedious to perform in field settings and require expertise to perform, among other problems. Solution The project team sought to develop a loop-mediated isothermal amplification (LAMP)…

…usual 6–12 months of daily antibiotic doses to one month. A large collection of wood-decaying fungi (WDF) were selected, from which eight different WDF isolates with interesting antimycobacterial activities were selected. These eight WDF were each cultured in a 10-litre liquid medium. Isolation of bioactive compounds from extracts with proven activity against S. auerus, E. coli,…

…Luweero Health Center HCIV for treatment. Using Pap smears, a total of 59 smears were diagnosed with abnormal cells. In addition to providing direct medical care, study activities averted morbidity and possible mortality. The study team will be applying to scale up the project and have identified  traditional research funding organizations, such as the U.S. National…

…urine, using an approach known as near infra-red spectroscopy (NIRS). NIRS monitors changes in hemoglobin concentration in the bladder wall, which enables the ‘health’ of the organ’s hemodynamics and oxygenation to be inferred. Where there is bladder obstruction, the organ's hemodynamics and oxygenation are affected and software in the NIRS device can identify in real…

…three key intervention areas: Birth preparedness, including mobilizing women to save towards safe delivery kits Transport Warm clothing to use at childbirth and after. Under birth preparedness, activities included mobilizing pregnant women into groups of 10 to form the “Star Parent mother clubs”. These groups met on a weekly basis to dialogue on issues of…

…identify novel agents that reverse resistance to mainstay antimalarial drugs, such as artemisinin. These new reversal agents will target heat shock protein 90 that can restore antimalarial activity. The team sought to identify an antimalarial compound derived from a West African traditional medicine demonstrated in pre-clinical trials to have potent activity. It is hoped this…