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Home » Innovations » 0264-01

Developing phytomedicines and pharmaceutical products against malaria using selected medicinal plants from Kenya and Nigeria

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Start Date: 01/04/2013- End Date: 31/12/2014


Project Lead(s): Patrick Were

Issue

Malaria has an estimated global incidence of about 500 million clinical cases annually and a corresponding mortality of up to 2.7 million.

The disease is prevalent in tropical countries, with sub-Saharan Africa bearing over 80% of the world’s malaria.

Solution

The aim of the project team was to develop phytomedicines and pharmaceutical products for use against malaria, using selected popular medicinal plants from Kenya and Nigeria.

Nearly 75% of Africans use herbal medicine, as they cannot access or afford conventional medicines.

By accessing medicinal plants already in use, the project undertook to add value and make them more accessible by producing the phytomedicine hygienically while, at the same time, dealing with dosage, packaging, formulation and safety challenges.

The team started by identifying useful plants already in use among the Kenyan communities.

Plant materials were extracted and tested in vitro and in vivo to establish their viability as treatment against malaria.

Malarial parasites were exposed to medicinal plant extracts and growth inhibition measured.

Outcome

Results obtained confirmed that the selected plants do possess potent antimalarial activities that could be harnessed.

The pharmaceutical potential of the selected plants was demonstrated by determining the phytoconstituents of the extracts.

The antimalarial effects observed can be attributed to secondary metabolites, such as alkaloids, flavonoids and sesquiterpenes found in the extracts.

The research team established a medicinal tree nursery to nurture medicinal tree seedlings. Training of herbalists on modern agronomical practices and how to add value to the herbal medicines they administer was also undertaken.

Further validation and formulation of a phytomedicine requires that all safety issues and dosage forms are established.

This is currently underway through drug escalation tests, and preclinical safety and efficacy studies in baboons at the Institute of Primate Research (IPR).

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    Program

    Stars in Global Health

    Institution

    Jomo Kenyatta University of Agriculture and Technology

    Institution Country

    Kenya

    Implementation Country

    Kenya, Nigeria

    Implementation Region

    Sub-Saharan Africa

    Priority

    Infectious Diseases, Malaria

    Platform

    Drug

Grand Challenges Canada’s programs are primarily undertaken with the financial support of the Government of Canada provided through Global Affairs Canada.

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