Accessibility Skip to:
  • Accessibility Policy
  • Main Content
  • Main Menu
  • Contact

  • -A: Font Smaller
  • +A: Font Larger
  • Reset Font
  • High Contrast
  • Low Contrast
  • Reset Contrast
History:
You are here:
  • Grand Challenges Canada
  • >
  • Innovations
  • >
  • 0253-01
  • Français
  • Get to Know Us
    • Who We Are
    • Co-CEOs
    • Governance
    • Accountability
    • The Team
    • Partnerships
    • Career Opportunities
    • Service Opportunities
    • Contact Us
  • Learn What We Do
    • What We Do
    • Global Health Innovation
    • Humanitarian
    • Indigenous
    • Transition To Scale
    • Innovative Financing
    • Innovations & Results
    • Annual Report
  • Apply for Funding
    • Funding Opportunities
    • Innovator Resources
    • Gender Equality Portal
  • Get Informed
    • News and Media
    • Blog
    • Publications
    • Subscribe
    • Photos and Videos
Grand Challenges Canada

Bold Ideas with Big Impact®

Browse our Innovations and Results
  • Get to Know Us
    • Who We Are
    • Co-CEOs
    • Governance
    • Accountability
    • The Team
    • Partnerships
    • Career Opportunities
    • Service Opportunities
    • Contact Us
  • Learn What We Do
    • What We Do
    • Global Health Innovation
    • Humanitarian
    • Indigenous
    • Transition To Scale
    • Innovative Financing
    • Innovations & Results
    • Annual Report
  • Apply for Funding
    • Funding Opportunities
    • Innovator Resources
    • Gender Equality Portal
  • Get Informed
    • News and Media
    • Blog
    • Publications
    • Subscribe
    • Photos and Videos
  • Accessibility
  • Contact
  • Français

Home » Innovations » 0253-01

Development of diagnostic kit for early and rapid detection of pulmonary and extrapulmonary tuberculosis and its evaluation in health centres

FacebookTwitterLinked In

Start Date: 01/04/2013- End Date: 31/12/2014


Project Lead(s): Ruchika Raghuvanshi

Issue

Tuberculosis (TB) causes millions of deaths annually, worldwide. In 2011, there were 8.7 million new TB cases and 1.4 million TB deaths.

The current gold standard for diagnosis by cell culture is slow and may result in further progression; molecular diagnostic techniques are promising but not widely used.

There is a need for a rapid and effective diagnostic tool that is suitable for use in low-income settings.

Solution

The project team proposed to develop a rapid, sensitive and specific diagnostic test (lipid antigen detection kit) for pulmonary and extra-pulmonary tuberculosis.

The project involved a number of steps:

·         identification of sero-reactive lipid antigens of tuberculosis

·         development of polyclonal antibodies against lipid antigens

·         development of monoclonal antibodies against lipid antigens

·         purification of monoclonal antibodies

·         development of a biosensor diagnostic platform.

Outcome

A lipid-based liposomal diagnostic technology has been developed for the first time for TB detection.

The technology does not require any specific instrument, either to perform or to evaluate the result, and also does not require any specialized technical expertise for evaluation.

The time required to perform the test is less than five minutes.

The test could prove to be an effective and rapid tool for the screening and diagnosis of tuberculosis. The plan is to develop a biochip using the isolated monoclonal antibodies IgG and IgM.

A patent application is pending for the technology.

The project team plans to apply for Phase II Transition To Scale funding, to scale the large-scale monoclonal antibody production against the desired lipid antigens of Mycobacterium tuberculosis, followed by screening of the monoclonal antibodies for diagnostic efficacy in a large population.

Stay in touch with this innovator

  • Organization Website
  • Network Website
  • Innovation Overview
    Program

    Stars in Global Health

    Institution

    Vikrant Educational and Social Welfare Society

    Institution Country

    India

    Implementation Country

    India

    Implementation Region

    South Asia

    Priority

    Infectious Diseases, Tuberculosis

    Platform

    Diagnostics / Diagnostics

Grand Challenges Canada’s programs are primarily undertaken with the financial support of the Government of Canada provided through Global Affairs Canada.

Government of Canada
  • Fluxx Technical Support
  • Privacy Policy
  • Website Legal Terms and Disclaimer
We use cookies on our website to give you the most relevant experience by remembering your preferences and activity on our website. By clicking “Accept All”, you consent to the use of ALL the cookies. However, you may click on "Cookie Settings" to select the cookies applicable to your activity and disable those that do not. Please note that you will not be able to disable all cookies as some are necessary for the functioning of the website.
Cookie Settings Accept All
Manage consent

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.
Necessary
Always Enabled
Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.
CookieDurationDescription
cookielawinfo-checkbox-analytics11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics".
cookielawinfo-checkbox-functional11 monthsThe cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
cookielawinfo-checkbox-necessary11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-others11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other.
cookielawinfo-checkbox-performance11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
viewed_cookie_policy11 monthsThe cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.
Functional
Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features.
Performance
Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.
Analytics
Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc.
Advertisement
Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. These cookies track visitors across websites and collect information to provide customized ads.
Others
Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet.
Save & Accept